If you are an Emacs user there is Org-Trello. Of course you would still be using the cloud platform. But that is handy on the mobile phone.: https://org-trello.github.io/
Related to notmuch is a client called 'alot'. Have a look at 'Email Workflow for Champions': http://deferred.io/posts/2013/01/13/email-workflow-for-champions.html
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If you are an Emacs user there is Org-Trello. Of course you would still be using the cloud platform. But that is handy on the mobile phone.: https://org-trello.github.io/
Related to notmuch is a client called 'alot'. Have a look at 'Email Workflow for Champions': http://deferred.io/posts/2013/01/13/email-workflow-for-champions.html